I’m The Only One With Genius DNA 150

I’m The Only One With Genius DNA chapter 150

Oh Hyun-dong, a judge of the Ministry of Food and Drug Safety’s Clinical Trial Review Committee (IRB), is one of Ryu’s supporters.

Of course, being a supporter does not mean that he gives generous clinical permission to the research he presents.

I was just amazed by the splendor of the future that the genius was creating.

Recently, there have been no incoming clinical trial requests from Avio.

It’s inevitable.

Recent anti-cancer research will be conducted in the United States and examined by the FDA.

A study conducted at the Karolinska Medical School in Sweden skipped clinical trials.

‘It’s also technically a clinical practice.’

There is nothing to say because the patient himself strongly demanded it and the government gave him permission after being recommended by the Swedish royal family.

What would the Korean Food and Drug Administration say about what happened in Sweden?

Cultured meat was also developed in the U.S., and when Ryu Young-joon was in the U.S., the FDA’s safety inspection is preceded, which reduces the number of work to be done by the Korean Food and Drug Administration.

Besides, it’s not a clinical trial.

In other words, I was bored these days.

The contrast is more clear when you think about the next time Ryu Young-joon made reverse differentiated stem cells.

It’s the first time I’ve developed a glaucoma treatment using stem cells, and it’s a treatment for Alzheimer’s, AIDS, and pancreatic cancer.….

It was hectic for months when there were tons of drugs pouring out.

“And you’re going to come up with another mysterious technique.”

Oh Hyun-dong, who had been surfing the boring web for a while at work, soon regretted the idea.

Because I got a call from Ryu Young-joon. What he said was pure astonishment.

“What are you going to do with mitochondria?”

Oh Hyun-dong screamed.

– Differentiate mitochondria extracted from human-derived cells into a proliferable form and then use them to transport genes. I want to insert 107 genes and send them to the patient’s brain and put them in the brain cells. They try to treat schizophrenia by allowing 107 genes to be expressed there.

“…….”

Oh Hyun-dong threw a pen that he had been writing down in his notebook at his desk.

“Dr. Ryu, this is…….This is going too far.”

He said so.

“It’s a common way to put genes into human cells with things like the Adeno Associate Virus (AAV).”

There’s no way to put 107 genes in that way. AAV has a small capacity, so it’s hard to put in even one gene.

“Why do you want to put 107 genes?”

That’s the only way I can cure schizophrenia.

“…….”

– I’m calling to check in advance how much preclinical data is needed to get permission for clinical trials with this. We will produce as much animal experiment data as you want.

“It’s such an unprecedented experiment that I can’t even set standards for animal testing. Dr. Liu, do you know why you use the AAV virus when you put genes into your body?”

Because it’s safe.

“That’s right. It’s proven safe. It is known that AAV enters the desired cells and does not multiply there. But what data do you have on the safety of the mitochondria that Dr. Liu is going to use?”

Isn’t it a clinical trial to produce that data? Clinical trials are supposed to be accompanied by risks.

“That’s… That’s him, but…….”

And the reason AAV is safe is because it doesn’t fit into the cell’s genes, right?

“That’s right……………..”

Mitochondria remain in the cytoplasm, not in the genes.

“That’s true.”

– And it does not proliferate within the human body because it requires high concentrations of methane. When you enter a human brain cell, only the genes are manipulated, but the biological activity is in the same state as the normal mitochondria.

“…….”

Setting this up well will be a great help in treating schizophrenia. I know it’s a bit of an unconventional experiment, but you have to take it with you. What do I need to get permission?

“Phew…… I’ll discuss it with the other judges. For now, make sure that the mitochondria that you use as a treatment only go into your brain cells and don’t travel anywhere else.”

***

What did he say?

Rosaline asked.

Rosaline asked.

“We need to get evidence that it doesn’t fit into other cells than brain cells.”

Ryu Young-joon replied.

It’s simple.

“But I’m curious, too. How do you get mitochondria into your brain cells specifically? It’s a much bigger creature than a virus. It won’t be easy to get in.”

-Just do it like you put it through an electric drill.

Rosaline replied.

“Give your brain micro-current stimulation?”

-No, the brain repeatedly damages and recovers the cell membrane a little at every moment because of the current flowing between neurons.

Rosaline said.

As long as the mitochondria stick to the brain’s target cells, they’ll get in on their own by a probability game. The mitochondria that failed to enter will be deactivated due to lack of methane and removed on their own.

“How do you implement sticking to target cells?”

– Among the genes introduced in mitochondria is a gene called D7T1.

“D7T1?”

– A dopamine receptor made of custom. If you have this, the mitochondria we make will track dopamine. Like a drug sniffer dog following the scent. Mitochondria will track it on their own on the dopamine pathway to the midbrain-variant system. And it sticks to cells with high dopamine activity.

“The cell with high dopamine activity is the cell that caused schizophrenia, so mitochondria in it?”

That’s right, there are over a thousand mitochondria in the cell. The mitochondria we give you as a drug will fit about 100 cells in one cell. That doesn’t affect the physiology of the cell much.

Rosaline said.

But the 107 genes that are expressed from that will inhibit dopamine production and control serotonin and glutamate to replace the drug.

‘Waaaah.

Ryu Young-joon burst into admiration.

Rosaline’s genius has been confirmed numerous times, but this time it’s really amazing.

When I first mentioned mitochondria, it was like a science fiction novel.

But now it’s in sight in a realistic way.

Science is the study of understanding.

It’s mysterious and magical when you don’t know it, but it’s natural and obvious when you know it.

The treatment of gene introduction through mitochondria was too obvious.

‘Well, let’s do a rat test.’

Ryu injected a solution containing mitochondria under two mice with a syringe.

But did Dr. Song Ji-hyun say that the schizophrenic patient’s condition was well-caught in the beginning?

Rosaline asked, while she was working for a long time.

“I think I did.”

– If you caught it well in the beginning, it’s not often suicidal. And when you ran into us a long time ago, you looked at it in sync mode, right? That’s a pretty serious condition.

“Really?”

-The disease has progressed a lot.

“But why did Dr. Song say that?”

I don’t know, maybe he didn’t want to tell you the details of his condition.

Rosaline said.

– I think you should meet him.

“Really?”

– No matter how good an animal experiment is, it may not be good enough for clinical use.

“Why?”

There’s a psychological factor that catalyzes Cho Hyun’s disease. It’s a disease where heredity accounts for half, and the environment accounts for half. In other words, genetically, dopamine-whining refers to a condition in which one is vulnerable to the disease. Environmentally, there is a psychological factor that “caused” the disease.

“…….”

– Of course, the latter is not impossible to replace with biology. Any psychological factor eventually leads to electrical signals in the brain or the expression of adrenaline and epinephrine.

Rosaline said.

But if you want to take it as a drug, you have to deal with a huge amount of variables, so thousands of times of clinical trial won’t be enough. I can suggest a way, but it’s not realistic.

“Okay, I’ll meet Dr. Song.”

Ryu Young-joon said as he put the rats in the cage.

***

When asked if he could meet her for a while, Song unexpectedly asked her to visit her house.

When asked if he could meet her for a while, Song unexpectedly asked her to visit her house.

It’s not my house, it’s my parents’ house. I came here for a while because I had something to do, but my parents are not here now. And I don’t have anyone to look after my sister. I don’t want to take her out to the cafe.…. Just come home.

She gave me her address.

I hung up the phone and got in the car, and I felt strange.

It is my first time visiting Song Ji-hyun’s house.

Don’t like it too much.

Rosaline said.

“Well, who likes it?”

I think my heart rate has gone up.

“Don’t mess with me. It’s because I’m nervous that I might make a mistake while asking about the patient.”

Ryu Young-joon traveled to the address given by Song Ji-hyun in a K-Cops security vehicle.

The security team waited in the car, and Ryu entered the apartment building alone.

The security guard, who was checking his identity at the entrance, was surprised to see Ryu Young-joon’s face.

“Dr. Ryu? Dr. Ryu Young-joon? Is it? Avio……?”

“That’s right.”

“Oh, my God!”

“I’m here in room 1402 for business. Put me through the intercom and they’ll let me know.”

Ryu Young-joon said.

Room 1402? Ah, that house…….”

Suddenly the guard’s expression got a little dark.

“What’s wrong?”

“No, and the daughter of the house told me to open the door at this hour.”

The guard pressed the door open button.

Security followed Ryu Young-joon, who was moving toward the elevator.

“But what’s going on in the house…….”

“I came to see her for a moment.”

“It’s not because of that psychopath, is it?

It sounded strange.

Ryu Young-joon glanced back at the guard.

“Mmmmmmmmm.

The guard covered his mouth and coughed in vain, then lowered his voice and said.

“Be careful. Dr. Liu, there’s a schizophrenic man in the house. You shouldn’t be attacking all of a sudden.”

“…. Is a schizophrenic attacking?”

“I’m not in my right mind, so it’s easier to kill…….You know. What if someone like Dr. Ryu gets hurt?”

“For every 100,000 people, 68 criminals commit violent crimes. What about the mentally ill?”

“What?”

“It’s about 33 per 100,000 people.”

“…….”

“If you have a condition of Cho Hyun-disease, you may have violent tendencies depending on the circumstances, but it doesn’t often lead to violent crimes.”

Ryu Young-joon said.

“There were actually three or four people who tried to kill me, but they were all sober, and the person who instigated them was a large corporate executive with considerable intelligence.”

“…….”

“Well, the preconception that mentally ill people commit murder easily is so widespread that it makes sense. I’m not blaming you. But they’re not demons or beasts.”

Ryu Young-joon said.

“I’m a patient.”

Wrong!

The elevator arrived on the first floor.

Ryu got on the elevator and pressed the 14th floor.

There was paper attached to the wall.

[Residents Survey.]

Which of the following factors has the greatest impact on falling real estate prices? (Put a sticker on the factor you think is correct.)

Which of the following factors has the greatest impact on falling real estate prices? (Put a sticker on the factor you think is correct.)

1. Patients with massive schizophrenia

2. Foreign Workers

3. Disabled

There were about 80 stickers attached to No. 1 alone.

“Tsk.”

Ryu Young-joon briefly kicked his tongue.

“Rosaline. Now I know why Dr. Song said that.”

He ripped the paper off.

I’m The Only One With Genius DNA chapter 150

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