I’m The Only One With Genius DNA 59

I’m The Only One With Genius DNA chapter 59

Ryu Young-joon established the hospital with funds raised through the Avio Public Interest Foundation.

After purchasing an old and large building in Mapo-gu, Seoul, it applied for repurposing and began renovation to a hospital.

Since the three phases of glaucoma are progressing smoothly, once the construction is completed and the hospital is opened, it will take the form of a general hospital and provide “glaucoma therapy” in earnest.

If one organoid is created by that time, it will be limited to the small intestine, but precise diagnostic treatment can also be carried out.

It is the first service of next-generation hospitals.

If stem cell research results are released one by one later, the scope of treatment will be expanded. Therefore, it is necessary to obtain more research results as soon as possible.

And it just so happens that luck has come to accelerate the research further.

“Long time no see.”

Carpentier, who visited Avio, shared a light hug with Ryu Young-joon.

Professor Carpentier of Caltech is a Nobel Prize winner.

He has long studied using stem cells to regenerate spinal cord nerves.

So did he succeed in restoring nerves with stem cells?

That’s not really. If that was the case, Ryu Young-joon wouldn’t be doing this.

Nobel Prize-winning achievements sometimes sound magical to people, just the case with Carpentier.

He ‘wirelessly connected’ the nerves of a patient with a broken spinal cord with an electric chip.

Stem cells were the main and one of several methodologies corresponding to Plan B was this, which eventually saw light from this side.

The spinal cord is a long collection of nervous systems that connect to the brain and descend all the way down the waist.

The clinical patient had damaged the upper part of the thoracic nerve and was unable to deliver commands from the brain down to the chest.

Carpentier inserted ultra-small electrical chips just up and down from the damaged area.

As a result, electrical signals from the excited nervous system were sent to live nerves underneath the chip when the patient thought he wanted to walk.

The patient succeeded in walking a few steps alone in four weeks, and Carpentier was awarded the Nobel Prize.

He had studied the project for about 20 years.

After successful monkey experiments, it took four years to get to the patient. It was such a careful study.

The U.S. government and Caltech University, which have poured research funds on him for 20 years, are great, but Carpentier, who succeeded with his tenacious determination, was also great.

But this technology still had its limits.

Patients recovered enough to walk, but could not run or bend flexibly.

We always had to be careful not to impact the back of the electric chip.

Above all, there was no cure if the nerve damage was higher than the chest nerve.

The technology to plant chips in the brain didn’t exist yet.

But Carpentier was now looking at the next hope in Ryu’s company.

“But Professor, aren’t you busy with school work? You said you’d join us in the second half, right?”

asked Ryu Young-joon.

“That’s right.”

Carpentier nodded.

“But now I’m a sabbatical and I don’t have any guidance students. I came a little early because I had about two months to deal with this and that.”

“Are you going back in two months?”

“Yes, and I’ll be back in the second half.”

“Oh, then please lead our team a lot for two months. I’m very happy that you’re here.”

“I’ll do my best.”

“Okay, but since you’re still in college, you have to write a short-term contract as an outside technical adviser.”

“All right.”

“Is everything all right with Caltech?”

“No, there are a lot of professors who are technical advisers to companies.”

“Okay.”

Ryu Young-joon wrote a contract through Park Joo-hyuk and received Carpentier’s signature.

“If you’re in the stem cell differentiation team, you’re comfortable with your spinal cord, right?”

Ryu Young-joon asked while scheduling the meeting.

“The bone marrow is fine.”

“The bone marrow is fine.”

“The nervous system and bone marrow are completely different fields.”

“I’ve been doing stem cells for a long time, and I’ve dug up a lot of them.”

Carpentier replied with a smile.

* * *

Jacob was a spinal cord regeneration team. Six other team members joined a spinal cord regeneration meeting for stem cells.

“Professor Capentier?”

Jacob’s eyes got bigger.

“Hello, Jacob. See you again.”

“What about school?”

“It’s sabbatical.”

“Now, let’s talk about the process.”

Ryu Young-joon said.

Not long after the project began, most of the presentations were detailed conditions of the experiment.

“…and now we’ve created a counter-differentiated stem cell, and we’re going to inject it into a spinal cord paralyzed model rat and then we’re going to differentiate it.”

Jacob finished his presentation.

He looked slightly nervously at Ryu Young-joon and Carpentier.

Carpentier spoke first.

“The biggest problem with planting stem cells directly is also the development of tumors. Do you have any ideas to solve this problem?”

“So in our project, we’ve adopted a mechanism of planting reverse differentiated stem cells in the affected area and then sending undifferentiated cells to the apoptosis mechanism.”

Jacob said.

“That’s a pretty good idea. But do undifferentiated cells deliver well to the apoptosis?”

“When spinal nerve differentiation progresses, the expression of the KRAK gene is suppressed. At the end of the gene, the cell suicide gene TP54 was cloned together and expressed.”

“Then in cells that don’t have neurodifferentiation, KRAK continues to manifest, and TP54 comes with it, and the cells die.”

Despite the difficult story, Carpentier quickly digested the core logic of the study. He is a Nobel Prize winner.

“But wouldn’t that kill the stem cells before they diverge?”

Carpentier asked.

“So the amount of cells that are successful in differentiation is small.

Ryu Young-joon replied instead.

“But you just have to put in a lot of stem cells from the beginning. If 10 nerves need to be recovered, we’ll put in 1,000. Then 990 are eliminated by cell suicides, and 10 survive are nerve-wracking.”

Carpentier nodded.

It seems like a rough way, but it is the safest, clearest and most effective way.

When treating type 2 diabetes with insulin, don’t you just take a large dose of insulin? Then even if the body’s insulin resistance is high and it doesn’t work well, it will eventually work. It’s the same as him.

The reason why this method has not been used in the past is because it was impossible to grow that many stem cells.

However, it is not difficult to use reverse differentiated stem cell technology.

If only one powerful new technology occurs, many problems can be solved together.

* * *

After the spinal cord meeting, Carpentier also attended a bone marrow regeneration meeting.

“The word bone marrow regeneration is exactly what makes hematopoietic cells?”

Carpentier pointed out.

“That’s right.”

Ryu Young-joon nodded.

A person’s bone marrow is a flexible tissue located in the inner space of the bone, which is a key organ that produces blood cells such as red blood cells and white blood cells.

So how do the bone marrow produce blood cells?

There is a hematopoietic cell that exists in a small proportion of about one-tenth of a million cells in bone marrow tissue.

They are a kind of stem cell.

However, it does not differentiate into all types of cells, such as embryonic stem cells or retro-differentiated stem cells.

The area where their ability to replicate themselves is limited to ‘blood cells’.

In other words, all the blood cells in the body are created by dividing hematopoietic cells in the bone marrow.

Thus, a treatment called “bone marrow transplantation” used to treat leukemia patients and others is hematopoietic stem cell transplantation, to be exact.

“We’re going to create hematopoietic cells from stem cells. And we’re going to transplant it into the patient’s bone marrow to cure various diseases.”

“We’re going to create hematopoietic cells from stem cells. And we’re going to transplant it into the patient’s bone marrow to cure various diseases.”

Ryu Young-joon said.

“Leukaemia will be the main target.”

Carpentier said.

“That’s right, we’re going to treat several blood diseases, including leukemia, with bone marrow regeneration.”

“Then let’s try one more thing while we’re at it.”

Carpentier threw the idea.

“What?”

“AIDS treatment.”

There was a moment of silence on the table.

“Can you cure AIDS with this?”

Dr. Lee Jung-hyuk, who was the team leader of the bone marrow regeneration team, asked.

“Yes, there is only one case in which AIDS has been completely cured in modern times.”

Carpentier said.

“Have you ever been cured of AIDS?”

Ryu Young-joon also found out for the first time.

“That’s right.”

Carpentier nodded.

I can’t help but admire it.

Rosaline knows all the triangulation of molecular biology, but it is limited to scientific facts.

Empirical knowledge. Rosaline is not sure about the actual history of science.

And Ryu Young-joon was originally an anti-cancer drug user.

AIDS is a viral infection, and it was a bit far from Ryu’s main field.

Carpentier, on the other hand, has been a top scientist in the industry for a long time, and has known many cases in many ways.

“The patient’s name is Timothy Ray Brown. He was once one of the most unhappy people in the world. Because.”

Carpentier said.

“I had AIDS and leukemia at the same time.”

“Oh, my God.”

Dr. Lee Jung-hyuk and members of the bone marrow regeneration team simultaneously let out a sigh.

Carpentier continued to explain.

“Both are famous and deadly incurable diseases. Timothy first received a bone marrow donation to treat leukemia.”

Out of about 60 donors, they managed to find someone with the right conditions and received a transplant. Fortunately, I was able to treat leukemia because it fit well.

But absurdly enough, the AIDS virus was not found in the body afterwards.

“AIDS viruses multiply by infecting and destroying white blood cells. Thanks to this, white blood cells continue to decrease, resulting in impaired immune system and death from complications called AIDS.”

Carpentier said.

“The hematopoietic cells in the donor’s bone marrow were resistant to AIDS. The hematopoietic cells-generated white blood cells are not infected with the AIDS virus.”

“…….”

“Over time, all non-AIDS-resistant white blood cells were destroyed and disappeared, and resistant white blood cells were newly established. The AIDS virus has been continuously reduced and eventually disappeared since there were no more infections.”

“There was a mutation in CCR5.”

Ryu Young-joon stepped in.

“That’s right.”

Carpentier nodded.

CCR5, one of the genes, is an infection channel for AIDS viruses. The white blood cells in which the gene works are infected with the AIDS virus. But the hematopoietic cells of the person who donated the bone marrow to Timothy Ray Brown had mutations in CCR5. The white blood cells from there had mutations.

“That’s an interesting example.”

Ryu Young-joon said. Carpentier grinned.

“The bone marrow that Timothy Ray Brown was implanted in had a natural mutation by accident. But if we can artificially turn bone marrow, or hematopoietic cells, into stem cells.”

He said so.

“Then why don’t we manipulate CCR5 and turn it into a bone marrow resistant to AIDS?”

“That’s a great idea.”

Ryu Young-joon said.

“But CEO. How do I operate the CCR5?”

“But CEO. How do I operate the CCR5?”

Dr. Lee Jung-hyuk asked.

Ryu Young-joon has been manipulating a lot of genes so far.

Most of them, however, used viruses to introduce external genes into cells.

It is completely different to cause specific mutations within genes that already exist in the cell.

“That’s the problem.”

Carpentier said with a frown.

“I think we should treat stem cells and DNA-damaging drugs at very low concentrations, and then pick out the mutations in CCR5.”

“Wouldn’t that take too long?”

Dr. Lee Jung-hyuk refuted.

“Technical advisor. It seems like the only way, but I think we need to check if there’s any variation other than CCR5. That’s going to be a lot of trouble.”

“It’s a bit of a hassle, but if that’s how you can cure an AIDS patient, then so be it.”

“Considering the labor force and the cost of sequencing, the price of the treatment will go up tremendously. It takes a very long time to treat one person. Wouldn’t it be hard to commercialize it?”

“Hmm… ”

Carpentier is in agony.

It is not easy to use genetic scissors that can cut parts of DNA.

Thousands, tens of thousands, of them will be cut at a time because they are experimenting with human genes as a whole.

We need scissors to cut off CCR5 exactly.

“There’s no other way. Maybe this isn’t a good project.”

Carpentier said with a bitter smile.

“There’s a way.”

Ryu Young-joon stepped in.

A message window was in front of his eyes.

[Synchronization mode: CCR5 -△32 Determine how to induce mutations. Fitness consumption: 1.7/1 seconds]

“I’ll do some research and tell you at the next meeting.”

I’m The Only One With Genius DNA chapter 59

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