I’m The Only One With Genius DNA 46
I’m The Only One With Genius DNA chapter 46
Ryu Young-joon said.
“I need you to analyze pancreatic cancer. You can do it now, right?”
Rosaline has risen a lot and she has improved her fitness. Now it has grown to the point where cancer can be opened.
There are two reasons for targeting pancreatic cancer.
First, late research on stem cell treatments is difficult to proceed immediately. It’s time for all the stem cell experts to focus on Alzheimer’s clinicians.
Second, by the time the project goes into full-fledged orbit, Avio will have already been created.
Then it becomes a study conducted as CEO of Avio, not as a researcher at Eisen. In other words, it means that Avio will enter the anti-cancer market.
It is true that public assessment of Avio is still focused on stem cells. Everyone thinks it’s a regenerative medicine company.
But Avio shouldn’t be such a company. This place should be a frontier who dominates all areas of the pharmaceutical industry. So I also brought Probiotics, a healthcare product.
Naturally, cancer, the biggest disease that threatens human health, is no exception. This will be a study that shows Avio’s identity.
So why target pancreatic cancer out of all the cancers? Pancreatic cancer accounts for only 2 percent of all cancer patients.
That’s because it’s the most difficult cancer to deal with.
Many advances have been made in almost all cancer species, but pancreatic cancer is still impregnable.
Calculating the survival rate within five years of cancer discovery, the average of cancer patients in Korea is 70 percent, with pancreatic cancer around 10 percent.
Even Steve Jobs, Apple’s CEO and most famous businessman, died of pancreatic cancer.
Wouldn’t a man like Steve Jobs do everything possible to bring all the best doctors in the world to life?
Still, he died. It means that it is still too difficult for mankind.
Why is it so hard?
Because there are few symptoms, most of them are already serious when they feel pain and receive medical treatment at the hospital.
And it is almost impossible to introduce treatment drugs into the pancreas.
Anti-cancer drugs are usually poisonous, so they can kill normal cells. Therefore, the key is to deliver it to cancer cells only.
This is called the local delivery of drugs, and the local delivery of pancreatic cancer treatments has been so difficult that numerous scientists have been devastated.
Because it is such a difficult disease, the impact on the anticancer drug field will be huge when conquered.
– It removes pancreatic cancer with coated Birnavirus.
The strategy of using viruses as a means of transportation for drug introduction is not so new. But most use viruses of the same species as AAV.
The virus was also unfamiliar to biologist Ryu Young-joon.
“What’s the Bernavirus?”
– A virus that causes infectious pancreatic necrosis in the salmon family. It’s a virus that destroys the pancreas and causes death.
“a virus that infects the salmon will work in human body?”
– It does not work on mammalian bodies.
No wonder it was unfamiliar.
It is a virus that is not contagious to humans. So the pharmaceutical industry wouldn’t have been very interested in the virus.
“Then how do you use it?”
– Manipulating a few receptors on the surface of the virus can only infect cancer cells in a person’s pancreas.
Images analyzed by Rosaline came to mind.
Four types of biomaterials rose on the surface of the virus.
Originally, they were materials that drilled into the surface of fish cells, but now their structure has changed and the mechanism of operation has changed.
The biomaterials recognized the structure of transferin receptors on the surface of pancreatic cancer cells and polymer substances called ERBB2.
Both are pancreatic cancer target materials that are expressed in large quantities only in pancreatic cancer cells.
The virus tore the membranes of pancreatic cancer cells and penetrated inside.
After a while, the cells infected with the Bernavirus activated the necrosis machine.
Pancreatic cancer cells began to die one by one.
– A virus that originally destroys the pancreas. It can also destroy tumors in the pancreas. It will be able to capture pancreatic cancer effectively.
Ryu Young-joon asked as he took his breath away from his hallucination.
“I have a lot to ask, but how do we introduce the virus? Intravenous administration?
-The pancreas is part of the digestive system, so you’d better go with the medicine you take. It’s more comfortable for patients.
“Okay, but that virus is a dangerous species. I don’t think we should leave it in the pancreas.”
If you remove the -BVP3 gene, it is impossible to multiply within the pancreas. The viruses you put in will be removed by macrophages after destroying the cancer cells. It is safe to administer the Bernavirus quantitatively enough to remove pancreatic cancer.
But there’s one more problem. Burnavirus is destroyed in the stomach.
Acid digestive fluid in gastric acid destroys the structure of the virus.
The pancreas is an organ connected to the duodenum, which is immediately after the gastric rift.
If you swallow the virus with your mouth, it means that you have to pass through the stomach to get access to the pancreas.
“Then I’ll have to make sure I can survive the stomach acid.”
-Structures can be modified to withstand stomach acid. But there’s another problem. Due to the nature of the digestive system, it stays in the stomach for a long time, and after that time, it eventually infects some of the stomach cells.
There are exceptions to all biology.
No matter how tightly controlled the drug is, it cannot be without side effects. Eventually, it touches normal cells little by little.
Naturally, the longer the exposure of normal cells, the higher the probability that drugs accidentally touch normal cells.
“If you lose activity in your stomach, you can’t go to the pancreas, and if you endure it, you infect your stomach?”
Yes, so rather than manipulating the virus itself to withstand stomach acid, we recommend coating the surface of the virus with capsules. This coating will withstand gastric acid but will be removed by pancreatic secretion.
“. Let’s summarize. Then, the capsule coating prevents the destruction of the virus and the infection of the gastric cells at the same time, then passes through the stomach and when the coating is destroyed by the pancreatic secretion, the oozing burna virus moves to the pancreas to infect only cancer cells, and induce it due to the nature of the virus. Activate necrosis to eliminate pancreatic cancer? At this point, the virus eliminates the ability to self-proliferate and puts in enough to destroy cancer cells, eliminating the side effects?”
Wow, is this for real?
In the meantime, it is a solution to the notoriety of countless scientists have kneeled down.
There is a reason why the medical community has yet to succeed. I can’t believe I have to drill in this creative way.
Once most scientists who study cancer don’t even know about the existence of a Bernavirus or something like that. Only scientists who study veterinary medicine or fishing.
The idea of infecting people by manipulating pathogens that infect fish flounders is also insane. Isn’t that a very perverse, dangerous, absurd imagination?
But you’re going to destroy pancreatic cancer by removing its ability to proliferate and making it work only in cancer cells?
In addition, the delivery process will be introduced only into the pancreas after passing the stomach with oral administration and capsule coating in response to interest?
It’s almost like a science fiction novel.
“There’s a reason why you whine that you can’t analyze cancer because you don’t have enough fitness.” What a complicated way.”
-Don’t worry. I can do most things now.
Options came to mind with Rosaline’s answer.
-See how to genetically manipulate the Vernavirus. (Fitness consumption: 1.0)
-View how to coat the Bernavirus capsule. (Fitness consumption: 1.5)
Ryu Young-joon opened each option, read it, and listened to the phone extension.
Following the guidance of the ARS, we followed the order of 1. purchase of experimental supplies, 2. purchase of experimental animals and genes, and 3. purchase of viruses.
Yes, I’m Kim Young Hee from Research Support Center.
“Hello, I’m Ryu Young-joon from the Life Creation Division.”
– Oh my god.
Kim Young-hee was startled.
Oh, yes. I’m sorry. How may I help you?
“I’m going to buy a Bernavirus.”
Kim Young-hee holds a doctorate in virology and is in charge of the virus at the research support center. Nevertheless, the Bernavirus was an unfamiliar species.
-······. I’m sorry, but what kind of virus is that?
She asked, hesitatingly.
It’s natural not to know. It’s not like Eisen is cooking salmon, so how do you know that?
I didn’t mean to embarrass you.
Ryu Young-joon relieved her confusion with a slight feeling of sorry.
“It’s a virus that causes infectious pancreatic necrosis from salmon.”
Salmon? Fish salmon?
Kim Young-hee asked in an absurd voice.
“Yes, it’s a salmon-infected virus. Is there a sample in the lab by any chance?
– No, it’s not. I know all the viruses in the lab, but I don’t have them.
Kim Young-hee said.
“How long will it take to buy it outside?”
Wait a minute.
Kim Young-hee said after searching the database.
– It will take about a month.
“Okay. Please proceed with the purchase. DNA vector status, please.”
Seven minutes’ walk from lab one.
There was a seven-story building with an area of 200 pyeong.
It was originally built as a separate research center by the First Laboratory and was intended to relocate the anti-cancer new drug department.
It was registered as a research institute and equipped with waste fluid treatment facilities, but it was not used due to poor circumstances.
Therefore, what came out for sale is now the office building of Avio.
“It’s smaller than I thought. I thought your name would be about 2,000 pyeong.”
Park Joo-hyuk, who came to see the building with Ryu Young-joon, said.
“But you don’t have to waste money already. We’re going to use all of the Azen facilities for production and research, and we just need to do the core research here, so that’s enough for now.”
“How many employees are there?”
“Seven so far.”
“······. One floor per person?”
“Does it make sense? Oh, no. Including me, there are eight.”
All of the life-creation departments have been transferred, and Choi Myung-joon and Seo Yoon-ju came in as they took over the probiotics business.
Choi Myung-joon, who was agonizing over leaving the conglomerate Eisen and going to A.V.O., enthusiastically persuaded Seo Yoon-ju. Director Ryu said it was a real golden rope.
“Do you have any intention of working as an in-house lawyer?”
asked Ryu Young-joon.
“Oh, I’m going to set up a legal team later when the company gets bigger. I’d like you to be in charge of that.”
Park Joo-hyuk folded his arms and was lost in thought for a moment.
“Okay, I don’t want to live off that kind of defense.”
“Okay, now nine. Let’s bring lawyer Lee Hye-won and fill up 10 people.”
“That’s a good idea, but why don’t you post a job notice? You’re not going to roll the company with just ten people, are you?”
“I’ve already paid.”
“I paid there ·····.”
Ryu Young-joon opened his cell phone.
There were about 40 job application emails in his mailbox.
And all the applicants are foreigners.
Park Joo-hyuk, who saw the cell phone screen, was shocked.
“Where the hell is the job application list with a name like Abdul Aziz? Do you see people in the Middle East these days?”
“I hired him for a science career job.”
“Wait. One of the applicants is Carpentier. Is this a real carpetier?
Ryu Young-joon’s hand trembled.
“Who’s the Capentier?”
“Don’t talk to me because I’m a bit of a mental breakdown right now.
Ryu Young-joon opened the mail.
I wondered if it was the same name, but when I read the story, it was true.
The first paragraph showed that fat stem cells were implanted to study skin tissue reconstruction. It was the carpetier that Ryu Young-joon knew.
“No, our company certainly has potential, but are you serious? What are you thinking? You’re coming to Korea without a tenure?
“Who the hell is that?”
Park Joo-hyuk replied as if he was frustrated.
“This is Professor Caltech. He won the Nobel Prize in Physiology and Medicine.”
Park Joo-hyuk’s mouth opened wide.
He stammered for a while and asked.
“That kind of person is coming to your company.
“I can’t believe it, but I have a supporting email right now.”
“······. Am I in the same boat with the Nobel Prize winner?”
“If you clean up Caltech, you’ll be my senior on the day you joined the company. Not by rank.”
“When he comes to Korea, reporters, do you know Ryu Young-joon? I’ll do it.”
Ryu Young-joon screamed at the terrible gukbap imagination.
“When the number of businesses and employees increases, we’ll move to a larger building.”
Ryu Young-joon replied.
I’m The Only One With Genius DNA chapter 46