I’m The Only One With Genius DNA 120

I’m The Only One With Genius DNA chapter 120

Royal Swedish Academy of Sciences (7)

Ryu Young-joon convened a task force team to test the side effects of immunogate inhibitors.

After receiving the e-mail, elite members of the Eisen Research Institute and Avio gathered.

There are about 30 people with all kinds of departments mixed.

Each country has its own nationality, and includes promising young doctors, professor-level personnel, and masters such as carpenters.

In terms of the sum of their research capabilities, they are people who can easily list at least one startup.

‘Oh, my God…’

Harriet saw them chattering together in a seminar room and shook his tongue.

Harriet, whose main job is a doctor, was busy working at the hospital, so she rarely attended the conference these days. It’s the first time I’ve seen them all at once.

I already heard that Ryu Young-joon brought the members to the conference, but it is quite shocking to see them in person.

Some of them can apply to Karolinska right away and get a teaching position.….’

It is also shocking that these big members are working for a company, but it is also mysterious that they even come to the conference and are called at Ryu Young-joon’s word.

“Scientists who usually hear masters don’t like to set their subjects or directions because of their pride.”….’

Clank.

The door to the seminar room opened.

Ryu Young-joon came inside and greeted the scientists lightly.

“Are you all enjoying the conference?”

“It was until the CEO called.”

Carpentier said with a smile.

“I’m sorry.”

“I’ve been to away lectures many times, but I’ve never done away research in my life.”

There was a light burst of laughter among the scientists.

“The purpose of this conference was a kind of vacation-like welfare that we put in place in the hope that you would take a break from listening to the lectures you want. But I feel bad about making you work all of a sudden.”

Ryu Young-joon said.

“But I’m so grateful and happy to see so many people volunteering for the experiment. So am I, but you’re also deeply rooted scientific nerds. As expected, I think I chose my colleagues well.”

“If you don’t be a fan of learning, it’s hard to study this much and make research a career.”

Ko Soon-yeol said, smoothing his glasses.

“Whoa, thank you. As I wrote in the e-mail, we will fully compensate you in the form of annual leave and performance pay.”

Ryu Young-joon said.

“I would have done it without such compensation because the subject of the study was interesting. I can’t let you work alone, so of course we’ll…….”

Choi Myung-joon stepped in with his hands up.

“Oh, Mr. Choi, that’s a little too much.”

Scientists around me gave me a hard time.

“Anyway, thank you. Everyone.”

Ryu Young-joon said.

“The lab rat will be supported by Professor Harriet here. Time fighting is an important experiment, so we’ll have to run some experiments at the same time.”

“Yes.”

“First, five life creation teams, including Dr. Chun Ji-myung, and four protein structure analysis teams, including Dr. Kim Myung-shin, will join forces to administer and control inhibitors to mice.”

Ryu Young-joon said.

“Just like a preclinical experiment, we need to test the level of drug emissions and toxicity. And monitoring of tumor size must be included. From Day 4, the tumor will hyperprogram and become huge in no time.”

Scientists look a little surprised.

It is the first time to talk about hyperprogress, although it is said that it is seeing side effects of immune gate inhibitors.

“Hyperprogress is coming?”

Carpentier asked.

“Yes, Dr. Carpentier, the research team on bone marrow differentiation of stem cells, and the first lab’s diagnostic instrument development department, please analyze the pharmacological mechanisms of hyperprogress in mice.”

“I see.”

“And Dr. Felicida’s team and Dr. Choi Myung-joon’s health and food department later sacrifice rats at the right time to make data on the size of the tumor.”

Ryu Young-joon has finished assigning roles.

***

***

In order to test anti-cancer drugs in the rat model, of course mice must have tumors.

That way, you can observe if the tumor decreases or not when you take anti-cancer drugs.

So how do you make a tumor in a rat’s body?

Drug treatment may naturally produce a tumor in a mouse, but it usually injects a human cancer cell into a mouse’s body and grows it into a tumor.

This method is called xenograft, a tumor.

“They’re mice that use cancer cells in non-small cell lung cancer patients (NSCLC) types to create tumors. The cell is known to have an EGFR mutation.”

Professor Harriet said, giving up 20 mice.

“We were originally going to use it as an experiment, but we’ll give you the time to wait for Genograph, so you can use it first.”

“Thank you. What are the cancer cells like?”

“It comes from lung cancer, and the cell phone number is HCC1010.”

It is certainly a cell known to have mutations in EGFR.

However, it is impossible to conduct experiments blindly by trusting existing data.

The status of the mutation in EGFR should be determined in advance.

“There’s a DNA analyzer in the Karolinska lab.”

Professor Harriet said.

“That’s great. Let me use it once.”

Ryu Young-joon said.

“But the technician that’s working on it isn’t here on vacation.Only…….”

“It’s okay. Our researchers can do it.”

Scientists from the Diagnostic Device Development Department of Eisen’s 1st Laboratory have stepped up.

“The technician you were using didn’t take care of the equipment properly. We’ll take care of the equipment.”

They said.

“….Thank you….….”

Professor Harriet nodded in an absurd mood.

They pulled data in just a half day.

Genome was extracted from cancer cells used in tumor production, amplified EGFR DNA, and read with DNA analysis equipment.

“Based on the report I received, there’s an L858R mutation in the EGFR. Is that right?”

The next morning, Ryu Young-joon told Professor Harriet.

“That’s right.”

Leucine, the 858 molecule of matter produced from the EGFR gene, has been transformed into arginine.

It is the most famous type of EGFR mutation and is a representative cancer-inducing mutation.

“Then give me some inhibitors.”

Ryu Young-joon said.

“Of course.”

Harriet gave some of the immunogate inhibitors she had at Karolinska Medical School for experimentation.

Life creation teams, including Chun Ji-myung, took immunogate inhibitors intravenously while raising mice in appropriate conditions.

The dosing cycle ranged from a small amount of 10 micrograms to a high capacity of 10 milligrams once a day.

It is divided into various conditions.

The Diagnostic Equipment Development Department used imaging devices to measure the size of tumors in rats’ lungs.

The tumor sizes of 20 mice were tracked at one-day intervals, respectively, respectively, stacked.

It’s been 3 days.

Hyperprogress has yet to appear in mice’s bodies.

Tumors have become slightly smaller than before, and the rats seem to be in good health.

***

“No way. It’s a drug that’s been commercialized.”

Jamie Anderson said.

“As we progressed to phase three, we administered drugs to 32 patients, and no hyperprogressions were observed.”

Oliver said.

“Ryu Young-joon is currently testing NSCLC-type lung cancer. Was there that type of patient?”

“….I don’t think so.”

“….I don’t think so.”

“There are many EGFR mutations in that type of lung cancer.”

“How is data built, such as whether clinical patients have EGFR mutations? We have blood and other samples, but we don’t analyze DNA.”

“The only people who do that right now are Avio’s next-generation hospital. But you can’t leave this alone. The Nobel Committee is a conservative group.”

Jamie said.

“Oliver, even if this experiment doesn’t have any side effects, people like Professor Harriet are possessed by Ryu, so I can reserve the Nobel Prize with a feeling of discomfort.”

“What should I do then?”

“Carolinska is a university hospital, not a medical lab. There are NSCLC patients here, too.

“Do you mean to use immunogate inhibitors on NSCLC-type lung cancer patients?”

“I heard you’re already in the middle of stage three lung cancer. Originally, immunogate inhibitors were supposed to be administered. Your doctor seems to be hesitant because Ryu Young-joon talked about the side effects this time. You should meet him.”

“Well…”

“If we cure them completely, Ryu will no longer insist on having side effects.”

“…….”

Oliver hesitated.

“It’s your own medicine, aren’t you confident?”

Jamie asked.

“That’s not true. Just…….”

Oliver blurted the end of his speech.

It is a new drug that he has researched for more than a decade.

It’s the same skill as a child.

Of course I believe it. Oliver was convinced of the drug effectiveness of immunogate inhibitors. I checked all the pharmacological mechanisms and saw that they were not toxic.

However, Ryu Young-joon is the opponent.

It is Ryu Young-joon, not a third-rate mother, who is pointing out the side effects of the new drug approved by the FDA.

That caught Oliver’s mind.

What if this technology, like a child, kills a man? Like Ryu Young-joon said, what if hyperprogress happens?

Can I handle the consequences?’

Jamie said to Oliver in agony.

“Oliver, it’s a drug that’s already been commercialized. Have more confidence. The FDA’s approval means it’s safe in the medical community as a whole. It’s not a clinical trial, it’s a normal ‘treatment’. The drug deserves to be administered to the patient.”

Jamie Anderson said.

***

Dr. Song Yura of the Diagnostic Equipment Development Department took over 20 mice from Chun Ji-myung’s team in the morning.

She used PET/CT equipment to stamp the rats’ lungs.

By day three, the tumor was half the size of her pinky fingernails.

I can only tell from the screen. And it was constantly shrinking.

But now on the fourth day.

Dr. Song Yura doubted his eyes.

“What…?”

The tumor has grown.

The size of the tumor has changed noticeably in mice with 100 micrograms of immune gate inhibitor.

In the bodies of mice administered 1 milligram and mice administered 10 milligram, the tumor was the size of a knuckles.

“…….”

How can it get so big all of a sudden?

Dr. Song Yu-ra took a picture and stored the data before observing other mice.

There was no problem in mice with very small doses of immunogate inhibitors, and mice with no control at all.

It’s obvious.

This is something that immunogate inhibitors have had an adverse effect on.

The tumor hasn’t gotten that big yet.

Is this really hyperprogress?

Her hands trembled.

It is FDA-approved and the most promising drug for years.

It was the most famous anti-cancer drug in the world until Ryu Young-joon appeared and produced pancreatic cancer treatments or cellicure.

It was the most famous anti-cancer drug in the world until Ryu Young-joon appeared and produced pancreatic cancer treatments or cellicure.

It was also an “immunity chemotherapy” that is expected to change the game in the anti-cancer market, along with chimera immunotherapy.

There is a side effect on that.’

Song Yu-ra sent the data to all the scientists involved in the study.

Soon Ryu Young-joon and Carpentier came running.

“Sacrify one set of mice you’re using in the experiment and analyze the pharmacology experimentally. The EGFR signal would have increased. Please check it out on Western Blot.”

Ryu Young-joon said.

There is a strong impact just by reporting side effects, but it is the scientist’s responsibility to find out the mechanism.

“And tell the rest of the rats to keep the life creation team on medication and conduct the experiment. From tomorrow, hyperprogress will be obvious.”

“I see.”

Dr. Song Yura replied.

Ryu Young-joon’s words are not wrong.

The next morning, the tumor nearly doubled in the rat’s body, which was given the largest dose of 10 milligrams of inhibitor.

A tumor about the size of two knuckles was a considerable burden on the body of the little mouse.

“Novascular production is also observed…….”

Scientists gathered behind Song Yu-ra’s back watched the monitor in dismay.

Cancer cells have spread.

“It’s hyperprogress.”

Carpentier said.

“This rat won’t live until tomorrow.”

Scientists glanced at Ryu Young-joon.

“Everyone worked hard to create important data. We still have more than a week until the appointment, so please secure all the data including the rest of the mice. And.”

Ryu Young-joon said.

“Write your thesis. I’ll talk to Science.”

I’m The Only One With Genius DNA chapter 120

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